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Clinical data
Other namesTestosterone 17β-trimethylsilyl ether; Testosterone O-trimethylsilyl ether; 17β-Trimethylsilyltestosterone; O-Trimethylsilyltestosterone; 17β-(trimethylsiloxy)androst-4-en-3-one; SC-16148; NSC-95147
Routes of
By mouth, intramuscular injection, subcutaneous injection
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.023.414 Edit this at Wikidata
Chemical and physical data
Molar mass360.613 g·mol−1
3D model (JSmol)

Silandrone (INN, USAN) (developmental code name SC-16148), also known as testosterone 17β-trimethylsilyl ether or 17β-trimethylsilyltestosterone, as well as 17β-(trimethylsiloxy)androst-4-en-3-one, is a synthetic anabolic-androgenic steroid (AAS) and an androgen ether – specifically, the 17β-trimethylsilyl ether of testosterone – which was developed by the G. D. Searle & Company in the 1960s but was never marketed.[1] It has a very long duration of action when given via subcutaneous or intramuscular injection, as well as significantly greater potency than that of testosterone propionate.[2][3] In addition, silandrone, unlike testosterone and most esters of testosterone like testosterone propionate, is orally active.[4]

See also[edit]


  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 642–. ISBN 978-1-4757-2085-3.
  2. ^ Saunders FJ (November 1966). "A singularly long-acting ether of testosterone". Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine. 123 (2): 303–4. doi:10.3181/00379727-123-31472. PMID 5951069.
  3. ^ Le Boeuf BJ, Allen JL (1970). "Prolonged reinstatement of sexual behavior in castrated male rats with an ether of testosterone, SC-16148". Hormones and Behavior. 1 (2). doi:10.1016/0018-506X(70)90004-8.
  4. ^ Chinn LJ (1969). The Chemistry and Biochemistry of Steroids. Geron-X. p. 97.