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Clinical data
Trade namesInfacol, Wind-eze, WindSetlers, many others
Other namessimethicone[1] (USAN US)
  • C
Routes of
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding0%
MetabolismNot metabolized
Elimination half-lifeN/A
  • Poly(dimethylsiloxane), silicon dioxide
CAS Number
PubChem CID
  • None
CompTox Dashboard (EPA)
ECHA InfoCard100.107.016 Edit this at Wikidata
Chemical and physical data
Formula(C2H6OSi)n · (SiO2)m
Molar massVariable
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Simeticone (INN), also known as simethicone (USAN), is an anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas.

Medical uses[edit]

Simethicone tablets

Simeticone is used to relieve the symptoms of excessive gas in the gastrointestinal tract, namely bloating, burping, and flatulence.[2][3] While there is a lack of conclusive evidence that simeticone is effective for this use,⁣[4][5][failed verification] studies have shown that it can relieve symptoms of functional dyspepsia[6] and functional bloating.[7]

It has not been fully established that simeticone is useful to treat colic in babies,[8] and it is not recommended for this purpose.[5] A study in the United Kingdom reported that according to parental perception simeticone helped infant colic in some cases.[9]

Simeticone can also be used for suspected postoperative abdominal discomfort in infants.[10]

Side effects[edit]

Simeticone does not have any serious side effects.[11] Two uncommon side effects (occurring in 1 in 100 to 1 in 1,000 patients) are constipation and nausea.[12]


Simeticone is a non-systemic surfactant which decreases the surface tension of gas bubbles in the GI tract.[11] This allows gas bubbles to leave the GI tract as flatulence or belching.[11] Simeticone does not reduce or prevent the formation of gas.[13] Its effectiveness has been shown in several in vitro studies.[14][15]


Simethicone is a mixture of dimethicone and silicon dioxide.[16]


The INN name is "simeticone", which was added to the INN recommended list in 1999.[17]

Simeticone is marketed under many brand names and in many combination drugs; it is also marketed as a veterinary drug.[18]


Brand names include A.F., Acid Off, Aero Red, Aero-OM, Aero-Sim, Aerocol, Aerox, Aesim, Aflat, Air-X, Anaflat, Antiflat, Baby Rest, Bicarsim, Bicarsim Forte, Blow-X, Bobotic, Bobotik, Carbogasol, Colic E, Colin, Cuplaton, Degas, Dentinox, Dermatix, Digesta, Dimetikon Meda, Disflatyl, Disolgas, Elugan N, Elzym, Endo-Paractol, Enterosilicona, Espaven Antigas, Espumisan, Espumisan L, Flacol, Flapex, Flatidyl, Flatoril, Flatulex, Flucolic, Gas X, Gas-X, Gaselab, Gaseoflat, Gaseoflatex, Gaseophar, Gaseoplus, Gaseovet, Gaservol, Gasimetin, Gasnil, Gasofilm, Gastrex, Gastrosen, Gazim X, Gazix, Geludrox-HS, Genasyme, Ilio-Funkton, Imogas, Imogaze, Imonogas, Infacalm, Infacol, Infacolic, Lefax, Lefaxin, Lefoam, Logastin, Luftal, Maxi Flat, Meteosim, Metiorisan, Metsil, Mylanta, Mylicon, Mylicongas, Mylom, Mymus, Nanog, Neodrop, Neogasol, Neolanta, Orocure, Ovol, Pedicon, Phazin, Phazyme, Restime, Rugby Gas Relief, Sab Simplex, Salinal, Semecon, Semeth, Sicongast, Siflat, Silbione, Siligas, Silipin, Sim, Simcone, Simecon, Simecrin, Simedill, Simegut, Simet, Simethicon, Simethicone, Simetic, Simeticon, Simeticona, Simeticone, Siméticone, Simeticonum, Simetigast, Simflat, Simicol, Simicon, Wilcon, Wind-eze and WindSetlers.[18]

It is also marketed as a combination drug:[18]

  • with algeldrate as Kestomatine
  • with aluminium or magnesium salts and in some cases both, as Alamag Plus, Almacone, Alposim, Aluphagel, Alutop, Amico-L Andursil, Axcel Eviline, Boots Wind Relief, Di-Gel, Diovol Plus, Diovol Plus AF, Gas Ban DS, Hydrosil, Iosopan Plus, Kremil, Kremil-S, Maalox Plus, Mi-Acid, Mygel, Mylagen, Polysilane Delalande, Rumibex and Trial AG
  • with alverine as Avarin, Meteospasmyl, Nady-Spasmyl
  • with barium sulfate as Bario Dif
  • with bismuth as Gastop
  • with calcium carbonate as Flamints, Gaseoflatex Plus, Malugel, Titralac Plus
  • with activated charcoal as Carbosylane, Clingest, Finigax. Flatuna
  • with cinitapride as Rogastril Plus
  • with clebopride as Flatoril
  • with dicycloverine as Cloact, Colicspam, Colimix, Colispas, Coliza-D, Cyclopam, Fri-Spas, Meftal Spas, Respas, Simcomine, Spasact, Spasmindon DPS
  • with domperidone as Bigetric, Dom Simecon, Doprokin-S, Glomoti, Moperidona AF, Mutecium, Praxis
  • with hydrotalcite as Altacide and Talsil Forte
  • with homatropine as Aero-Sim Compuesto, Asestor, Factor AG, Sedotropina Flat
  • with lactulose as Dinolak
  • with levonorgestrel as Jaydess
  • with loperamide as Eldoper Plus, Imodium Duo, Imolopesim, Loperamide HCl/Dimeticon, Loperuma, Lositala, Losiwuto, Regulane AF, Stoperan Plus, Toban F Plus
  • with magaldrate as Aci Basic, Aci-Tip, Acicone-S, Acid-Farvet, Acifin, Amalset, Antiax, Asidrat, Assis, Avicid, Banacid-s, Buenox, Cremalon, Curecid, Digax, Digeril, Endcid, Gaseovet MS, Gastrine, Gastrogel, Gastroral, Gastrorapid, Magacid, Magal-D, Magalat, Magaldrato+Simeticona, Magaldrax, Maganta Plus, Magsilon, Marlox Plus, Megacil Plus, Megalrat Plus, Minicidez, Miopan Plus, Novelta, Oxecone-MS, Riopan Plus, Rolac Plus, Sedo Mag, Simagal, Simelgat Plus, Taimacon, Zymcon
  • with metoclopramide as Anaflat Compuesto, Di-Aero OM, Digespar, Factorine, Pangastren
  • with mosapride as M-Pride-MPS, Moxar, Moza MPS
  • with pancreatin as Anaflat Enzimático, Digenil, Digesflat, Enzym Lefax, Enzymet, Enzymin, fermento duodenal, Finigax Indigestion, Flaton, Flazymec, Gasflat, Gaszym, Gesdyp, Hazmolin, Komflat, MeteoZym, Pankreoflat, Tripanzym
  • with papaverine as Espasmo Siligas
  • with pinaverium as Alevian Duo, Pladuet, Planex
  • with pipenzolate bromide as Cadinol, Gasorbol Gotas
  • with phloroglucinol as Meteoxane
  • with trimebutine as Eumotil-S, Eumotrix Plus, Libertrim SDP, Libertrim SII, Muvett S
  • with urea as Hidribet.

It is also marketed as a veterinary drug under the brands Birp and Methysilox.


  1. ^ "Simethicone names". Retrieved 27 August 2017.
  2. ^ "Simethicone tablet". NIH DailyMed. April 2016. Retrieved 27 August 2017.
  3. ^ "Simeticone". NHS. 10 October 2019. Retrieved 30 January 2020.
  4. ^ Modi R, Clearfield HR, Levitt M (July 2013). "Belching, Bloating and Flatulence". American College of Gastroenterology.
  5. ^ a b "Simethicone". Efficacy not established for the symptomatic relief of immediate postprandial upper abdominal distress
  6. ^ Holtmann G, Gschossmann J, Mayr P, Talley NJ (September 2002). "A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia". Alimentary Pharmacology & Therapeutics. Wiley. 16 (9): 1641–8. doi:10.1046/j.1365-2036.2002.01322.x. PMID 12197843. S2CID 23286985.
  7. ^ Burta O, Iacobescu C, Mateescu RB, Nicolaie T, Tiuca N, Pop CS (25 September 2018). "Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, randomised, double-blind, parallel group, clinical study". Translational Gastroenterology and Hepatology. AME Publications. 3 (72): 72. doi:10.21037/tgh.2018.09.11. PMC 6256934. PMID 30511026.
  8. ^ Biagioli E, Tarasco V, Lingua C, Moja L, Savino F (September 2016). "Pain-relieving agents for infantile colic". The Cochrane Database of Systematic Reviews. 2016 (9): CD009999. doi:10.1002/14651858.CD009999.pub2. PMC 6457752. PMID 27631535.
  9. ^ Goldman M, Beaumont T (March 2017). "A real world evaluation of a treatment for infant colic based on the experience and perceptions of 4004 parents". British Journal of Nursing. 26 (5 Suppl 1): S3–S10. doi:10.12968/bjon.2017.26.Sup5.S3. PMID 28350192. S2CID 32885530.
  10. ^ Voepel-Lewis TD, Malviya S, Burke C, D'Agostino R, Hadden SM, Siewert M, Tait AR (March 1998). "Evaluation of simethicone for the treatment of postoperative abdominal discomfort in infants". Journal of Clinical Anesthesia. 10 (2): 91–94. doi:10.1016/S0952-8180(97)00249-3. PMID 9524891.
  11. ^ a b c Ingold CJ, Akhondi H (January 2021). "Simethicone". StatPearls [Internet]. PMID 32310457.
  12. ^ "Simethicone Side Effects in Detail". Retrieved 27 August 2017.
  13. ^ "Treatment of Gas". International Foundation for Functional Gastrointestinal Disorders. 4 September 2015.
  14. ^ Brecević L, Bosan-Kilibarda I, Strajnar F (May 1994). "Mechanism of antifoaming action of simethicone". Journal of Applied Toxicology. Wiley. 14 (3): 207–11. doi:10.1002/jat.2550140311. PMID 8083482. S2CID 7453218. Retrieved 30 January 2020.
  15. ^ Dittrich M, Miederer SE, Havertz B, Krastev R (12 May 2010). "Schaumzerstörung und Schaumverhinderung: Der Wirkmechanismus von Simeticon in vitro" [Defoaming and antifoaming action of simethicone in vitro] (PDF). Journal für Gastroenterologische und Hepatologische Erkrankungen. (in German). Krause & Pachernegg. 8 (3): 19–25.
  16. ^ O'Neil MJ, ed. (2006). "Dimethicone". The Merck Index (14th ed.). Whitehouse Station, NJ: Merck. p. 545.
  17. ^ "Recommended INN List 42" (PDF). WHO Drug Information. 13 (3): 202. 1999.
  18. ^ a b c "Simeticone international brands". Retrieved 27 August 2017.