|Trade names||Infacol, Wind-eze, WindSetlers, many others|
|Synonyms||simethicone (USAN US)|
|Chemical and physical data|
|Formula||(C2H6OSi)n · (SiO2)m|
|(what is this?)|
Simeticone is used to relieve the symptoms of excessive gas in the gastrointestinal tract, namely bloating, burping, and flatulence. There is a lack of evidence that simeticone is effective for this use.
Efficacy has not been fully established that simeticone is useful to treat colic in babies, and it is not recommended for this purpose; however, evidence is sparse. In 2017, a study in the United Kingdom reported that according to parental perception simeticone helped infant colic in some cases.
There are no known side effects of simeticone.
Simeticone is an anti-foaming agent that decreases the surface tension of gas bubbles, causing them to combine into larger bubbles in the digestive tract. Simethicone does not reduce or prevent the formation of gas.
Society and culture
The INN name is "simeticone", which was added to the INN recommended list in 1999.
Brand names include A.F., Acid Off, Aero Red, Aero-OM, Aero-Sim, Aerocol, Aerox, Aesim, Aflat, Air-X, Anaflat, Antiflat, Baby Rest, Bicarsim, Bicarsim Forte, Blow-X, Bobotic, Bobotik, Carbogasol, Colic E, Colin, Cuplaton, Degas, Dentinox, Dermatix, Digesta, Dimetikon Meda, Disflatyl, Disolgas, Elugan N, Elzym, Endo-Paractol, Enterosilicona, Espaven Antigas, Espumisan, Espumisan L, Flacol, Flapex, Flatidyl, Flatoril, Flatulex, Flucolic, Gas X, Gas-X, Gaselab, Gaseoflat, Gaseoflatex, Gaseophar, Gaseoplus, Gaseovet, Gaservol, Gasnil, Gasofilm, Gastrex, Gastrosen, Gazim X, Gazix, Geludrox-HS, Genasyme, Ilio-Funkton, Imogas, Imogaze, Imonogas, Infacalm, Infacol, Infacolic, Lefax, Lefaxin, Lefoam, Logastin, Luftal, Maxi Flat, Meteosim, Metiorisan, Metsil, Mylanta, Mylicon, Mylicongas, Mylom, Mymus, Nanog, Neodrop, Neogasol, Neolanta, Orocure, Ovol, Pedicon, Phazin, Phazyme, Restime, Rugby Gas Relief, Sab Simplex, Salinal, Semecon, Semeth, Sicongast, Siflat, Silbione, Siligas, Silipin, Sim, Simcone, Simecon, Simecrin, Simedill, Simegut, Simet, Simethicon, Simethicone, Simetic, Simeticon, Simeticona, Simeticone, Siméticone, Simeticonum, Simetigast, Simflat, Simicol, Simicon, Wilcon, Wind-eze, and WindSetlers.
It is also marketed as veterinary drug under the brands Birp and Methysilox.
- "Simethicone names". Drugs.com. Retrieved 27 August 2017.
- "Simethicone tablet". NIH DailyMed. April 2016. Retrieved 27 August 2017.
- Modi, Ronak; Clearfield, Harris R.; Levitt, Michael (July 2013). "Belching, Bloating, and Flatulence". American College of Gastroenterology.
- "Simethicone". drugs.com.
Efficacy not established for the symptomatic relief of immediate postprandial upper abdominal distress
- Biagioli, E; Tarasco, V; Lingua, C; Moja, L; Savino, F (16 September 2016). "Pain-relieving agents for infantile colic" (PDF). The Cochrane Database of Systematic Reviews. 9: CD009999. doi:10.1002/14651858.CD009999.pub2. PMID 27631535.
- Goldman, M; Beaumont, T (2017). "A real world evaluation of a treatment for infant colic based on the experience and perceptions of 4004 parents". British Journal of Nursing. 26 (5): Suppl 1 (S1 – S12). PMID 8350192.
- "Simethicone Side Effects in Detail - Drugs.com". Drugs.com. Retrieved 27 August 2017.
- "Treatment of Gas". International Foundation for Functional Gastrointestinal Disorders. 4 September 2015.
- "Recommended INN List 42" (PDF). WHO Drug Information. 13 (3): 202. 1999.
- "Simeticone international brands". Drugs.com. Retrieved 27 August 2017.