Simian hemorrhagic fever virus

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Simian hemorrhagic fever virus
Virus classification
Group: Group IV ((+)ssRNA)
Order: Nidovirales
Family: Arteriviridae
Genus: Arterivirus
Species: Simian hemorrhagic fever virus

Simian hemorrhagic fever virus or simian haemorrhagic fever virus or SHFV is a highly pathogenic virus in monkeys. It is a positive-stranded RNA virus classified in the family Arteriviridae.


Patas are believed to be the natural host for the virus since about 50% of wild patas monkeys have antibodies for the virus, while antibodies are much less prevalent in other simian species such as vervets and baboons. In macaques, however, infection with this virus can result in acute severe disease with high mortality. Recently, red colobus monkeys and red-tailed guenons have been identified as natural hosts for SHFV.[1][2]


Asymptomatic infection of the virus can occur in patas monkeys, vervet monkeys, and baboons, although it is observed primarily in patas monkeys. Infection has a rapid onset with animals developing a high fever, facial edema, cyanosis, anorexia, melena, and may begin to hemorrhage at the cutaneous, subcutaneous, and retrobulbar levels. Thrombocytopenia will develop soon after. Death usually occurs within 10–15 days after symptoms appear.[3]


  1. ^ Lauck, Michael; Hyeroba, David; Tumukunde, Alex; Weny, Geoffrey; Lank, Simon M.; Chapman, Colin A.; O'Connor, David H.; Friedrich, Thomas C.; Goldberg, Tony L. (2011). "Novel, Divergent Simian Hemorrhagic Fever Viruses in a Wild Ugandan Red Colobus Monkey Discovered Using Direct Pyrosequencing". PLoS ONE. 6 (4): e19056. Bibcode:2011PLoSO...619056L. doi:10.1371/journal.pone.0019056. PMC 3081318Freely accessible. PMID 21544192. 
  2. ^ Lauck, M.; Sibley, S. D.; Hyeroba, D.; Tumukunde, A.; Weny, G.; Chapman, C. A.; Ting, N.; Switzer, W. M.; Kuhn, J. H.; Friedrich, T. C.; O'Connor, D. H.; Goldberg, T. L. (2012). "Exceptional Simian Hemorrhagic Fever Virus Diversity in a Wild African Primate Community". Journal of Virology. 87 (1): 688–91. doi:10.1128/JVI.02433-12. PMC 3536393Freely accessible. PMID 23077302. 
  3. ^ Hirsh, Dwight C.; MacLachlan, N. James; Walker, Richard L. (2004). Veterinary Microbiology (2nd ed.). Blackwell. ISBN 978-0-8138-0379-1. [page needed]