Luttichuys was born in London. According to the RKD he was probably the same person as Simon Littlehouse who painted a portrait of the bishop Thomas Morton of St. John's College, Cambridge in 1637/1638. His name in Dutch sounds like Littlehouse. He was the brother of the painter Isaack Luttichuys and had moved to Amsterdam by 1649. He married an Englishwoman from Norfolk in Amsterdam in 1655, Anna van Peene uit ' Naerfick in Engelant'. He is known for various forms of still life painting and influenced the painter Willem Kalf. He died in Amsterdam.