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Shepherd was born in Bristol, England. He went to school at Clifton College in Bristol and was a contemporary of the director Roger Michell in Brown's House. He subsequently attended Manchester Metropolitan University and Bristol Old Vic Theatre School and was a member of the National Youth Theatre.
As well as his television appearances he has had many notable stage and film roles since 1980. In 2015 he revealed he is unable to feel physical pain and considers himself "a shadow of his former self".
In popular culture
Simon Shepherd was regularly mentioned in the BBC Comedy Gimme Gimme Gimme as Tom's crush and appeared as himself in an episode of each series.
He played the role of Sir Norman Cavendish in the play The Duck House by Dan Patterson and Colin Swash, starring alongside Ben Miller and Diana Vickers. The show is a political farce based on the UK parliamentary expenses scandal of 2009 and played a five-week tour in October 2013 before transferring to London's Vaudeville Theatre through Spring 2014.
He married the costume designer Alexandra Byrne in 1980 and they have four children. Shepherd supports several charities, especially those involving the well-being of children (Barnardo's, Tearfund BOPS and Save the Children).
- "The Duck House: MPs' expenses satire heads for West End". bbc.co.uk/news. BBC News. 16 September 2013. Retrieved 16 September 2013.
- "Political Comedy The Duck House Will Play London's Vaudeville; Cast Announced". playbill.com. Playbill. 16 September 2013. Retrieved 20 September 2013.