Simone Esposito began his youth career with Juventus in 2002, and remained within the club's youth program until 2008. He began to earn first team call-ups by former coaches Claudio Ranieri in 2008 and again by Ciro Ferrara in 2009. Esposito made his first team debut on December 10, 2008 in a 2008–09 UEFA Champions League game against FC BATE Borisov. He also played one game in the Coppa Italia. In the summer of 2010, the attacking midfielder officially graduated the youth team, and was promoted into the senior squad. Following his installment, he was instantly loaned out to Serie B side, Ascoli Calcio, as part of a player exchange, that also was used in attempt to gain regular playing time. Esposito is one of many Juventusloaners, flooding ItalianSerie B and Serie C football.