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Virus classification
Group: Group I (dsDNA)
Order: Herpesvirales
Family: Herpesviridae
Subfamily: Alphaherpesvirinae
Genus: Simplexvirus
Type species
Human herpesvirus 1

Human herpesvirus 1 Human herpesvirus 2

Simplexvirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Alphaherpesvirinae. Humans and mammals serve as natural hosts. There are currently 11 species in this genus including the type species Human herpesvirus 1. Diseases associated with this genus include: skin vesicles or mucosal ulcers, rarely encephalitis and meningitis.[1][2]


Group: dsDNA



Viruses in Simplexvirus are enveloped, with icosahedral, Spherical to pleomorphic, and Round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 152kb in length.[1]

Genus Structure Symmetry Capsid Genomic arrangement Genomic segmentation
Simplexvirus Spherical Pleomorphic T=16 Enveloped Linear Monopartite

Life cycle[edit]

Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral gB, gC, gD and gH proteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. Translation takes place by leaky scanning. The virus exits the host cell by nuclear egress, budding, and microtubular outwards viral transport. Human and mammals serve as the natural host. Transmission routes are sexual, contact, and saliva.[1]

Genus Host details Tissue tropism Entry details Release details Replication site Assembly site Transmission
Simplexvirus Humans; mammals Epithelial mucosa Cell receptor endocytosis Budding Nucleus Nucleus Saliva


  1. ^ a b c "Viral Zone". ExPASy. Retrieved 15 June 2015. 
  2. ^ a b ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015. 

External links[edit]