Sini Jose (Malayalam: സിനി ജോസ്) (born 25 May 1987) is an Indian sprint athlete from Ernakulam district, Kerala who specializes in 400 metres. Sini won the Gold Medal at the 2010 Commonwealth Games and 2010 Asian Games in 4x400 m relay event with Manjeet Kaur, A. C. Ashwini, and Mandeep Kaur.
Sini hails from Avoli, a village in Muvattupuzha, Ernakulam district, Kerala. Born to Mundackal Jose Joseph and Rithamma Jose, Sini is an employee of Indian Railways at Ernakulam.
Her personal best for 400 m is 53.01 s achieved during the Federation Cup athletics meet in Ranchi on 2 May 2010 where she won a gold medal.