He was the eldest son of Sir John Guise, 1st Baronet (1733–1794), of Highnam Court, whom he succeeded in 1794, inheriting Highnam Court. He also inherited the Gloucestershire estates of Elmore Court, the original seat of the Guise family, and Rendcomb, on the death in 1807 of his cousin Jane Guise, wife of Shute Barrington (1734-1826), Bishop of Durham.
He was educated at Eton College (1791) and at Christ Church, Oxford (1794). In 1801 he was appointed verderer and deputy warden of the Forest of Dean, which office he retained until his death. In 1807 he was appointed Sheriff of the City of Gloucester and in 1813 as Mayor of Gloucester. He served as an officer in both the North Gloustershire Militia (1798) and the Royal East Gloucestershire Militia (1809).
Death & succession
- Kidd, Charles, Debrett's peerage & Baronetage 2015 Edition, London, 2015, p.B355; As displayed above front door of Elmore Court
- "GUISE, Sir Berkeley William, 2nd Bt. (1775-1834), of Highnam Court, Glos". History of Parliament Online. Retrieved 2013-03-09.