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Structure of siroheme

Siroheme (or sirohaem) is a heme-like prosthetic group used by some enzymes to accomplish the six-electron reduction of sulfur and nitrogen.[1] Siroheme is synthesized from uroporphyrinogen III, a heme and vitamin B12 precursor.[2] It plays a major role in the sulfur assimilation pathway: converting sulfite to a biologically useful sulfide, which can be incorporated into the organic compound homocysteine.[3]

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