The mušḫuššu (𒈲𒄭𒄊; formerly also read as sirrušu, sirrush) is a creature depicted on the reconstructed Ishtar Gate of the city of Babylon, dating to the 6th century B.C. As depicted, it is a mythological hybrid: a scaly dragon with hind legs resembling the talons of an eagle, feline forelegs, a long neck and tail, a horned head, a snake-like tongue, and a crest.
The form mušḫuššu is the Akkadian nominative of the Sumerian 𒈲𒄭𒄊 MUŠ.ḪUS, lit. "reddish snake" sometimes also translated as "fierce snake". One author, possibly following others, translates it as "splendor serpent" (𒈲 MUŠ is the Sumerian term for "serpent". The reading sir-ruššu is due to a mistransliteration in early Assyriology.).
The constellation Hydra was known in Babylonian astronomical texts as 𒀯 𒀭 𒈲 MUL.dMUŠ, “the serpent (with divine and star determinatives)”. It was depicted as a snake drawn out long with the forepaws of a lion, no hind-legs, with wings, and with a head comparable to the mušḫuššu dragon.  This monstrous serpent may have inspired the Lernaean Hydra of Greek mythology and ultimately the modern Hydra constellation.
Bel and the Dragon, a deuterocanonical Biblical text, relates a story that Koldewey thought involved a mušḫuššu/sirrush. In a temple dedicated to Bel (Nebuchadnezzar's god), priests had a "great dragon or serpent, which they of Babylon worshipped."
Daniel, the protagonist of the Book of Daniel, was confronted with this creature by the priests in the apocryphal text. (see Additions to Daniel) They challenged him to match his invisible God against their living god. Eventually, Daniel poisoned the creature.
German archeologist Robert Koldewey, who discovered the Ishtar Gate in 1902, seriously considered the notion that the sirrush was a portrayal of a real animal. He argued that its depiction in Babylonian art was consistent over many centuries, while those of mythological creatures changed, sometimes drastically, over the years. He also noted that the sirrush is shown on the Ishtar Gate alongside real animals, the lion and the rimi (aurochs), leading him to speculate the sirrush was a creature the Babylonians were familiar with. The creature's distinctly feline front paws seemed incongruous, and gave Koldewey some doubt. However, in 1918, he proposed that Iguanodon (a dinosaur with birdlike hindfeet) was the closest match to the sirrush (Sjögren, 1980).
- Hydra (constellation)
- Behemoth, a beast mentioned in the Tanach (Old Testament)
- The beast (Revelation), two beasts described in the New Testament
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