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Sixtus was a Roman name, a corruption of the Greek name "Ξυστος," meaning "polished," and originally Latinized "Xystus." In its Spanish form Sixto it is still used as a personal name. It is not to be confused with the common Roman praenomen "Sextus," meaning "sixth," though not necessarily denoting a sixth child.

Notable people named Sixtus include five Popes of the Roman Catholic Church, the first three of whom are called "Xystus" in the most ancient records:

Other notable people named Sixtus include:

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