Sjögren syndrome antigen B

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SSB
Protein SSB PDB 1owx.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SSB, LARP3, La, La/Sjogren syndrome antigen B
External IDs MGI: 98423 HomoloGene: 2366 GeneCards: SSB
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SSB
Genomic location for SSB
Band 2q31.1 Start 169,791,933 bp[1]
End 169,812,064 bp[1]
RNA expression pattern
PBB GE SSB 201138 s at fs.png

PBB GE SSB 201139 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003142
NM_001294145

NM_001110145
NM_009278
NM_001355265

RefSeq (protein)

NP_001281074
NP_003133

NP_001103615
NP_033304
NP_001342194

Location (UCSC) Chr 2: 169.79 – 169.81 Mb Chr 2: 69.86 – 69.87 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sjögren syndrome type B antigen (SS-B) also known as Lupus La protein is a protein that in humans is encoded by the SSB gene.[5]

Function[edit]

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjögren's syndrome and systemic lupus erythematosus.[5][6]

Interactions[edit]

Sjögren syndrome antigen B has been shown to interact with nucleolin.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138385 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068882 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: SSB Sjögren's syndrome antigen B (autoantigen La)". 
  6. ^ Teplova M, Yuan YR, Phan AT, Malinina L, Ilin S, Teplov A, Patel DJ (January 2006). "Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen". Molecular Cell. 21 (1): 75–85. doi:10.1016/j.molcel.2005.10.027. PMID 16387655. 
  7. ^ Fouraux MA, Bouvet P, Verkaart S, van Venrooij WJ, Pruijn GJ (July 2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". Journal of Molecular Biology. 320 (3): 475–88. doi:10.1016/S0022-2836(02)00518-1. PMID 12096904. 

Further reading[edit]