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Skp1 (S-phase kinase-associated protein 1) is a small protein of approximately 160 amino acids. As a core component of the SCF-type E3 ubiquitin ligases that mediate protein degradation by the 26S proteosome, Skp1 plays key roles in cell-cycle progression, transcriptional regulation, signal transduction, and many other cellular processes in eukaryotes.


Hellmann, H. and Estelle, M. (2002) Plant development: regulation by protein degradation. Science, 297, 793–797.