Small-blue-round-cell tumor

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Small blue round cells of Ewing Sarcoma
Display of small round blue cells characteristic of desmoplastic small round cell tumour.

In histopathology, a small-blue-round-cell tumour (abbreviated SBRCT), also known as a small-round-blue-cell tumor (SRBCT) or a small-round-cell tumour (SRCT), is any one of a group of malignant neoplasms that have a characteristic appearance under the microscope, i.e. consisting of small round cells that stain blue on routine H&E stained sections.

These tumors are seen more often in children than in adults. They typically represent undifferentiated cells. The predominance of blue staining is because the cells consist predominantly of nucleus, thus they have scant cytoplasm.[1][2]


Tumors that belong to this group are:

Conditions mimicking SBRCT[edit]

Endometrial stromal condensation may mimic a small-blue-round-cell tumour.

Endometrial stromal condensation may mimic a small-blue-round-cell tumour.


  1. ^ a b Gregorio A, Corrias MV, Castriconi R, et al. (July 2008). "Small round blue cell tumours: diagnostic and prognostic usefulness of the expression of B7-H3 surface molecule". Histopathology. 53 (1): 73–80. PMC 2658025Freely accessible. PMID 18613926. doi:10.1111/j.1365-2559.2008.03070.x. 
  2. ^ Khan, Javed; Wei, Jun; Saal, Lao; Marc, Ladanyi; Markus, Ringnér; Peterson, Carsten; Chen, Yidong; Meltzer, Paul (April 2001). "Development of a molecular taxonomy of small blue round-cell tumors using cDNA microarrays". Nature Genetics. 27 (4s): 64–64. doi:10.1038/87150. 
  3. ^ a b c d e Chen QR, Vansant G, Oades K, et al. (February 2007). "Diagnosis of the small round blue cell tumors using multiplex polymerase chain reaction". J Mol Diagn. 9 (1): 80–8. PMC 1867426Freely accessible. PMID 17251339. doi:10.2353/jmoldx.2007.060111. 
  4. ^ Gray W, Kocjan G. Diagnostic Cytopathology; . p.307