Small multidrug resistance protein

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Small Multidrug Resistance protein
Symbol Multi_Drug_Res
Pfam PF00892
Pfam clan CL0184
InterPro IPR000390
SCOP 1s7b
TCDB 2.A.7
OPM superfamily 70
OPM protein 5i20

Small multidrug resistance protein (also known as Drug/Metabolite Transporter) is a family of integral membrane proteins that confer drug resistance to a wide range of toxic compounds by removing them for the cells. The efflux is coupled to an influx of protons. An example is Escherichia coli mvrC P23895 which prevents the incorporation of methyl viologen into cells[1] and is involved in ethidium bromide efflux.[2]


  1. ^ Morimyo M, Hongo E, Hama-inaba H, Machida I (1992). "Cloning and characterization of the mvrC gene of Escherichia coli K-12 which confers resistance against methyl viologen toxicity". Nucleic Acids Res. 20 (12): 3159–3165. doi:10.1093/nar/20.12.3159. PMC 312453Freely accessible. PMID 1320256. 
  2. ^ Purewal AS (1991). "Nucleotide sequence of the ethidium efflux gene from Escherichia coli". FEMS Microbiol. Lett. 66 (2): 229–231. doi:10.1111/j.1574-6968.1991.tb04870.x. PMID 1936950. 
This article incorporates text from the public domain Pfam and InterPro: IPR000390