Small nucleolar RNA Me18S-Gm1358

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Small nucleolar RNA Me18S-Gm1358
RF00533.jpg
Predicted secondary structure and sequence conservation of snoMe18S-Gm1358
Identifiers
Symbol snoMe18S-Gm1358
Rfam RF00533
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

Small nucleolar RNA Me18S-Gm1358 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Me18S-Gm1358 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] It is predicted that this family directs 2'-O-methylation of 18S G-1358.[2]

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