Small nucleolar RNA Me28S-Cm3227

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Small nucleolar RNA Me28S-Cm3227
RF00536.jpg
Predicted secondary structure and sequence conservation of snoMe28S-Cm3227
Identifiers
Symbol snoMe28S-Cm3227
Rfam RF00536
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

Small nucleolar RNA Me28S-Cm3227 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Me28S-Cm3227 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] It is predicted that this family directs 2'-O-methylation of 28S C-3227.[2]

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