Small nucleolar RNA Me28S-U3344

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Small nucleolar RNA Me28S-U3344
RF00526.jpg
Predicted secondary structure and sequence conservation of snoMe28S-U3344
Identifiers
SymbolsnoMe28S-U3344
Alt. SymbolssnoMe28S-U3344a; sno28S-U3344a
RfamRF00526
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GO0006396 0005730
SO0000593
PDB structuresPDBe

Small nucleolar RNA Me28S-Um3344 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Me28S-Um3344 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] It is predicted that this family directs 2'-O-methylation of 28S U-3344.[2]

References[edit]

  1. ^ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ^ Huang ZP, Zhou H, He HL, Chen CL, Liang D, Qu LH (August 2005). "Genome-wide analyses of two families of snoRNA genes from Drosophila melanogaster, demonstrating the extensive utilization of introns for coding of snoRNAs". RNA. 11 (8): 1303–16. doi:10.1261/rna.2380905. PMC 1370813. PMID 15987805.

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