Small nucleolar RNA R105/R108

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Small nucleolar RNA R105/R108
Type: Gene; snRNA; guide; CD-box;
2° structure: Predicted; Griffiths-Jones S
Seed alignment: Moxon SJ
Avg length: 103.3 nucleotides
Avg identity: 77%

Small nucleolar RNA R105/R108 refers to a group of related non-coding RNA (ncRNA) molecules which function in the biogenesis of other small nuclear RNAs (snRNAs). These small nucleolar RNAs (snoRNAs) are modifying RNAs and usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis.

These two snoRNAs called R105 and R108 were identified in the plant Arabidopsis thaliana[1] and are predicted to belong to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[2]


  1. ^ Marker, C.; Zemann, A.; Terhörst, T.; Kiefmann, M.; Kastenmayer, J. P.; Green, P.; Bachellerie, J. P.; Brosius, J. R.; Hüttenhofer, A. (10 December 2002). "Experimental RNomics: identification of 140 candidates for small non-messenger RNAs in the plant Arabidopsis thaliana". Current Biology. 12 (23): 2002–2013. doi:10.1016/S0960-9822(02)01304-0. PMID 12477388. 
  2. ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041Freely accessible. PMID 12215523. 

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