Small nucleolar RNA SNORA73

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Small nucleolar RNA SNORA73 family
Symbol SNORA73
Alt. Symbols U17
Rfam RF00045
Other data
RNA type Gene; snRNA; snoRNA; HACA-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000594
PDB structures PDBe

In molecular biology, the small nucleolar RNA SNORA73 (also called U17/E1 RNA) belongs to the H/ACA class of small nucleolar RNAs (snoRNAs). Vertebrate U17 is intron-encoded and ranges in length from 200-230 nucleotides, longer than most snoRNAs. It is one of the most abundant snoRNAs in human cells and is essential for the cleavage of pre-rRNA within the 5' external transcribed spacer (ETS).[1] This cleavage leads to the formation of 18S rRNA. Regions of the U17 RNA are complementary to rRNA and act as guides for RNA/RNA interactions, although these regions do not seem to be well conserved between organisms.[2]

See also[edit]


  1. ^ Enright, CA; Maxwell ES; Eliceiri GL; Sollner-Webb B (1996). "5'ETS rRNA processing facilitated by four small RNAs: U14, E3, U17, and U3". RNA. 2 (11): 1094–1099. PMC 1369439Freely accessible. PMID 8903340. 
  2. ^ Cervelli, M; Cecconi F; Giorgi M; Annesi F; Oliverio M; Mariottini P (2002). "Comparative Structure Analysis of Vertebrate U17 Small Nucleolar RNA (snoRNA)". J Mol Evol. 54 (2): 166–179. doi:10.1007/s00239-001-0065-2. PMID 11821910. 

External links[edit]