Small nucleolar RNA SNORA73

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Small nucleolar RNA SNORA73 family
Alt. SymbolsU17
Other data
RNA typeGene; snRNA; snoRNA; HACA-box
GO0006396 0005730
PDB structuresPDBe

In molecular biology, the small nucleolar RNA SNORA73 (also called U17/E1 RNA) belongs to the H/ACA class of small nucleolar RNAs (snoRNAs). Vertebrate U17 is intron-encoded and ranges in length from 200-230 nucleotides, longer than most snoRNAs. It is one of the most abundant snoRNAs in human cells and is essential for the cleavage of pre-rRNA within the 5' external transcribed spacer (ETS).[1] This cleavage leads to the formation of 18S rRNA. Regions of the U17 RNA are complementary to rRNA and act as guides for RNA/RNA interactions, although these regions do not seem to be well conserved between organisms.[2]

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  1. ^ Enright, CA; Maxwell ES; Eliceiri GL; Sollner-Webb B (1996). "5'ETS rRNA processing facilitated by four small RNAs: U14, E3, U17, and U3". RNA. 2 (11): 1094–1099. PMC 1369439. PMID 8903340.
  2. ^ Cervelli, M; Cecconi F; Giorgi M; Annesi F; Oliverio M; Mariottini P (2002). "Comparative Structure Analysis of Vertebrate U17 Small Nucleolar RNA (snoRNA)". J Mol Evol. 54 (2): 166–179. doi:10.1007/s00239-001-0065-2. PMID 11821910.

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