Small nucleolar RNA SNORD110

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Small Nucleolar RNA SNORD110
RF00610.jpg
Predicted secondary structure and sequence conservation of SNORD110
Identifiers
Symbol SNORD110
Rfam RF00610
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593
PDB structures PDBe

Small Nucleolar RNA SNORD110 (also known as HBII-55) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

HBII-55 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] HBII-55 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) at residue U1288.[2]

References[edit]

  1. ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041Freely accessible. PMID 12215523. 
  2. ^ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX 10.1.1.105.7552Freely accessible. doi:10.1093/nar/gkj002. PMC 1347365Freely accessible. PMID 16381836. 

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