Small nucleolar RNA SNORD111

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Small Nucleolar RNA SNORD111
RF00611.jpg
Predicted secondary structure and sequence conservation of SNORD111
Identifiers
Symbol SNORD111
Rfam RF00611
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

Small Nucleolar RNA SNORD111 (also known as HBII-82) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

SNORD111 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] SNORD111 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) at residue G3923.[2][3] The exact role of these molecules, however, is not currently known.

References[edit]

  1. ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. PMC 134041Freely accessible. PMID 12215523. doi:10.1128/MCB.22.19.6663-6668.2002. 
  2. ^ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX 10.1.1.105.7552Freely accessible. PMC 1347365Freely accessible. PMID 16381836. doi:10.1093/nar/gkj002. 
  3. ^ Huttenhofer, Alexander; Kiefmann, Martin; Meier-Ewert, Sebastian; O'Brien, John; Lehrach, Hans; Bachellerie, Jean-Pierre; Brosius, Jürgen (1 June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–2953. PMC 125495Freely accessible. PMID 11387227. doi:10.1093/emboj/20.11.2943. 

External links[edit]