Small nucleolar RNA SNORD24

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Small nucleolar RNA SNORD24
Symbol SNORD24
Alt. Symbols U24
Rfam RF00069
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

U24 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs.[1] C/D box snoRNAs have been shown to act as methylation guides for a number of RNA targets.[2][3] U24 is encoded within an intron of the gene for ribosomal protein L7a in mammals, chicken and Fugu.[4] The U76/SNORD76 snoRNA is found in an intron of the uRNA host gene (UHG) growth arrest specific 5 (GAS5) transcript gene.[5] snoRNAs Z20 and U76 snoRNAs show clear similarity to U24.

An experiment that looked at 22 different non-small-cell lung cancer tissues found that SNORD33, SNORD66 and SNORD76 were over-expressed relative to matched noncancerous lung tissues.[6]


  1. ^ Qu, Liang-Hu; Henry, Yves; Nicoloso, Monique; Michot, Bernard; Azum, Marie-Claude; Renalier, Marie-Hélène; Caizergues-Ferrer, Michele; Bachellerie, Jean-Pierre (25 July 1995). "U24, a novel intron-encoded small nucleolar RNA with two 12 nt long, phylogenetically conserved complementaritiesm to 28S rRNA". Nucleic Acids Research. 23 (14): 2669–2676. PMC 307091Freely accessible. PMID 7651828. doi:10.1093/nar/23.14.2669. 
  2. ^ Nicoloso, M.; Qu, L. H.; Michot, B.; Bachellerie, J. P. (July 1996). "Intron-encoded, Antisense Small Nucleolar RNAs: The Characterization of Nine Novel Species Points to Their Direct Role as Guides for the 2′-O-ribose Methylation of rRNAs". Journal of Molecular Biology. 260 (2): 178–195. PMID 8764399. doi:10.1006/jmbi.1996.0391. 
  3. ^ Kiss-László, Zsuzsanna; Henry, Yves; Bachellerie, Jean-Pierre; Caizergues-Ferrer, Michèle; Kiss, Tamás (June 1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell. 85 (7): 1077–1088. PMID 8674114. doi:10.1016/S0092-8674(00)81308-2. 
  4. ^ Gilley, J.; Fried, M. (July 1998). "Evolution of U24 and U36 snoRNAs Encoded within Introns of Vertebrate rpL7a Gene Homologs: Unique Features of Mammalian U36 Variants". DNA and Cell Biology. 17 (7): 591–602. PMID 9703018. doi:10.1089/dna.1998.17.591. (Subscription required (help)). 
  5. ^ Hirose, Tetsuro; Steitz, Joan A. (6 November 2001). "Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells". Proceedings of the National Academy of Sciences. 98 (23): 12914–12919. JSTOR 3057015. PMC 60799Freely accessible. PMID 11606788. doi:10.1073/pnas.231490998. 
  6. ^ Liao, Jipei; Yu, Lei; Mei, Yuping; Guarnera, Maria; Shen, Jun; Li, Ruiyun; Liu, Zhenqiu; Jiang, Feng (2010). "Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer". Molecular Cancer. 9: 198. PMC 2919450Freely accessible. PMID 20663213. doi:10.1186/1476-4598-9-198. 

External links[edit]