Small nucleolar RNA SNORD25

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Small nucleolar RNA SNORD25
Symbol SNORD25
Alt. Symbols U25
Rfam RF00054
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

snoRNA U25 (also known as SNORD25) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

U25 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

U25 is found in gene clusters in plants [2] and within the U22 snoRNA host gene (UHG) in mammals.[3] U25 is thought to as a 2'-O-ribose methylation guide for ribosomal RNA. This RNA has also been named snoRNA R73 in some plants.


  1. ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041Freely accessible. PMID 12215523. 
  2. ^ Qu LH, Meng Q, Zhou H, et al. (2001). "Identification of 10 novel snoRNA gene clusters from Arabidopsis thaliana". Nucleic Acids Res. 29 (7): 1623–30. doi:10.1093/nar/29.7.1623. PMC 31268Freely accessible. PMID 11266566. 
  3. ^ Tycowski KT, Shu MD, Steitz JA (1996). "A mammalian gene with introns instead of exons generating stable RNA products". Nature. 379 (6564): 464–6. doi:10.1038/379464a0. PMID 8559254. 

External links[edit]