Small nucleolar RNA SNORD44

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Small nucleolar RNA SNORD44
Symbol SNORD44
Alt. Symbols U44
Rfam RF00287
Other data
RNA type Gene; snRNA; snoRNA; C/D-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

snoRNA U44 (also known as SNORD44) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U44 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

U44 was originally cloned from HeLa cells and expression verified by northern blotting.[2] It is predicted to guide 2'O-ribose methylation of 18S ribosomal RNA(rRNA) at residue A166.[3] In the human genome, U44 is located in the same gene as several other C/D box snoRNAs (U47, U74, U75, U76, U77, U78, U79, U80 and U81).[3]


  1. ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. PMC 134041Freely accessible. PMID 12215523. doi:10.1128/MCB.22.19.6663-6668.2002. 
  2. ^ Kiss-László, Zsuzsanna; Henry, Yves; Bachellerie, Jean-Pierre; Caizergues-Ferrer, Michèle; Kiss, Tamás (June 1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell. 85 (7): 1077–1088. PMID 8674114. doi:10.1016/S0092-8674(00)81308-2. 
  3. ^ a b Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX accessible. PMC 1347365Freely accessible. PMID 16381836. doi:10.1093/nar/gkj002. 

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