Small nucleolar RNA TBR5

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Small nucleolar RNA TBR5
RF00292.jpg
Predicted secondary structure and sequence conservation of snoTBR5
Identifiers
Symbol snoTBR5
Rfam RF00292
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593

TBR5 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]

References[edit]

  1. ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.  edit
  2. ^ Dunbar, DA; Wormsley S; Lowe TM; Baserga SJ (2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". J Biol Chem 275 (19): 14767–14776. doi:10.1074/jbc.M001180200. PMID 10747997. 

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