Small nucleolar RNA U2-19

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Small nucleolar RNA U2-19
RF00494.jpg
Predicted secondary structure and sequence conservation of snoU2_19
Identifiers
Symbol snoU2_19
Rfam RF00494
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000593
PDB structures PDBe

Small nucleolar RNA U2-19 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA U2-19 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] snoRNA U2-19 directs 2'-O-methylation of U2 spliceosomal RNA G-19.[2]

References[edit]

  1. ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041Freely accessible. PMID 12215523. 
  2. ^ Tycowski, KT; Aab A; Steitz JA (2004). "Guide RNAs with 5' Caps and Novel Box C/D snoRNA-like Domains for Modification of snRNAs in Metazoa". Curr Biol. 14 (22): 1985–1995. doi:10.1016/j.cub.2004.11.003. PMID 15556860. 

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