Small nucleolar RNA Z161/Z228

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Small nucleolar RNA Z161/Z228
Predicted secondary structure and sequence conservation of snoZ161_228
Alt. SymbolssnoZ161
Other data
RNA typeGene; snRNA; snoRNA; CD-box
GOGO:0006396 GO:0005730
PDB structuresPDBe

In molecular biology, Small nucleolar RNA Z161 (homologous to snoRNA Z228) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA Z161 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]

Plant snoRNA Z161 was identified in a screen of Oryza sativa.[3]


  1. ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ^ Kiss, T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell. 109 (2): 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400. S2CID 8968788.
  3. ^ Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH (2003). "The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa". Nucleic Acids Res. 31 (10): 2601–13. doi:10.1093/nar/gkg373. PMC 156054. PMID 12736310.

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