Small nucleolar RNA Z221

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Small nucleolar RNA Z221/R21b
RF00300.jpg
Predicted secondary structure and sequence conservation of snoZ221_snoR21b
Identifiers
Symbol snoZ221_snoR21b
Alt. Symbols snoZ221
Rfam RF00300
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0001263

Small nucleolar RNA Z221 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA Z221 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

Plant snoRNA Z221 was identified in a screen of Oryza sativa.[2]

References[edit]

  1. ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. PMC 134041Freely accessible. PMID 12215523. doi:10.1128/MCB.22.19.6663-6668.2002. 
  2. ^ Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH (2003). "The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa". Nucleic Acids Res. 31 (10): 2601–13. PMC 156054Freely accessible. PMID 12736310. doi:10.1093/nar/gkg373. 

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