Small nucleolar RNA psi28S-3327

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Small nucleolar RNA psi28S-3327
Predicted secondary structure and sequence conservation of snopsi28S-3327
Symbol snopsi28S-3327
Rfam RF00544
Other data
RNA type Gene; snRNA; snoRNA; HACA-box
Domain(s) Eukaryota
GO 0006396 0005730
SO 0000594

Small nucleolar RNA psi28S-3327 (also known as snoRNA psi28S-3327) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.

This Drosophila specific snoRNA is a member of the H/ACA box class of snoRNA and is predicted to be responsible for guiding the modification of uridine 3327 in Drosophila 28S and U1920 in Drosophila 18S rRNA to pseudouridine.[1]


  1. ^ Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology. 24 (13): 5797–5807. PMC 480876Freely accessible. PMID 15199136. doi:10.1128/MCB.24.13.5797-5807.2004. 

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