The song was covered in 1985 by Mötley Crüe. Released as a single, "Smokin' in the Boys Room" reached #16 on the U.S. Billboard Hot 100, and became Mötley Crüe's first Top 40 hit. Their version of the song appears in the 1986 film The Wraith directed by Chieffallo. A Leann Rimes version of the song appeared on the album Nashville Outlaws: A Tribute To Mötley Crüe.
Crüe's version was accompanied by a conceptual music video featuring Michael Berryman as the school principal. The video focuses on a high school student named Jimmy who is mistreated and misunderstood in school. After he is punished for (truthfully) claiming that a dog ran off with his homework, a frustrated Jimmy goes to the boys' bathroom where he sees Motley Crüe in the mirrors. The band pulls him through the mirror to join them, and Jimmy and Motley Crüe watch a dystopian vision of the school through a barred window.
In 1981, the song was translated to Hebrew and covered by T-Slam under the name "Me'ashnim Beyahad" (Smoking Together) on their debut album. The English version of the album, "Loud Radio" featured another cover of the song, this time in English.