Sodium aurothiosulfate

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Sodium aurothiosulfate
Na3Au(S2O3)2.png
Sodium-gold(I)-thiosulfate-dihydrate-unit-cell-3D-balls.png
Systematic (IUPAC) name
trisodium dithiosulphate aurate(I), dihydrate
Clinical data
Routes of
administration
Intramuscular injection
Identifiers
CAS Number 18497-75-1 YesY
ATC code M01CB02 (WHO)
PubChem CID 170028
Chemical data
Formula AuNa3O6S4
Molar mass 332.08452 g/mol
  (verify)

Sodium aurothiosulfate is the inorganic compound with the formula Na3Au(S2O3)2·2H2O. This salt contains an anionic linear coordination complex of gold(I) bound to two thiosulfate ligands.[1][2] Like several other gold compounds, this species is used as an antirheumatic.[3]The first placebo-controlled trial was probably conducted in 1931, when sanocrysin was compared with distilled water for the treatment of tuberculosis.[4]

References[edit]

  1. ^ Baggio, R (1973). "Crystal and molecular structure of trisodium dithiosulphate aurate(I), dihydrate, Na3[Au(S2O3)2],2H2O". Journal of Inorganic and Nuclear Chemistry. 35 (9): 3191. doi:10.1016/0022-1902(73)80019-3. 
  2. ^ Tobön-Zapata, G (1997). "Vibrational spectrum of Sanocrysin". Spectrochimica Acta Part a Molecular and Biomolecular Spectroscopy. 53 (2): 183. doi:10.1016/S1386-1425(97)83024-7. 
  3. ^ Shaw, III, C. F. (1999). "Gold-Based Therapeutic Agents". Chemical Reviews. 99 (9): 2589–600. doi:10.1021/cr980431o. PMID 11749494. 
  4. ^ Ethical and regulatory aspects of clinical research: readings and commentary, Ezekiel J. Emanuel, Johns Hopkins University Press, 2003, p 140

Source of Chemical Formula: http://medical.merriam-webster.com/medical/gold%20sodium%20thiomalate