Sodium butyrate
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| Names | |
|---|---|
| Preferred IUPAC name
Sodium butanoate | |
| Other names
Sodium butyrate | |
| Identifiers | |
3D model (JSmol) |
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| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.005.326 |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| CH3CH2CH2COONa | |
| Molar mass | 110.088 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Sodium butyrate is a compound with formula CH3CH2CH2COO−Na+. It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expression.[1] As such, it can be used in lab to bring about any of these effects. Specifically, butyrate treatment of cells results in histone hyperacetylation, and butyrate itself inhibits class I histone deacetylase (HDAC) activity,[2] specifically HDAC1, HDAC2, HDAC3, and butyrate can be used in determining histone deacetylene in chromatin structure and function. Inhibition of HDAC activity is estimated to affect the expression of only 2% of mammalian genes.[3]
Sodium butyrate is a white, water-soluble, crystalline solid. Samples have the odor of butyric acid.[4] When working with sodium butyrate, gloves, eye protection and respiratory masks are advised for safety purposes.[5]
Sodium butyrate has been found to be effective in the prevention of traveler's diarrhea.[6][7]
See also
[edit]References
[edit]- ↑ Kruh, Jacques (1981). "Effects of sodium butyrate, a new pharmacological agent, on cells in culture". Molecular and Cellular Biochemistry. 42 (2): 65–82. doi:10.1007/BF00222695. PMID 6174854. S2CID 24214720.
- ↑ Candido, E; Reeves, Raymond; Davie, James R. (1978). "Sodium butyrate inhibits histone deacetylation in cultured cells". Cell. 14 (1): 105–13. doi:10.1016/0092-8674(78)90305-7. PMID 667927. S2CID 33206068.
- ↑ Davie, James R. (2003). "Inhibition of Histone Deacetylase Activity by Butyrate". The Journal of Nutrition. 133 (7 Suppl): 2485S–2493S. doi:10.1093/jn/133.7.2485s. PMID 12840228.
- ↑ "Sodium butanoate | 156-54-7". Chemicalbook.com. Retrieved 2016-05-31.
- ↑ "Sodium butyrate ≥98.5% (GC) | Sigma-Aldrich". Sigmaaldrich.com. Retrieved 2016-05-31.
- ↑ Fan H, Gao L, Yin Z, Ye S, Zhao H, Peng Q (October 2022). "Probiotics and rifaximin for the prevention of travelers' diarrhea: A systematic review and network meta-analysis". Medicine (Baltimore). 101 (40): e30921. doi:10.1097/MD.0000000000030921. PMC 9542755. PMID 36221413.
{{cite journal}}: CS1 maint: article number as page number (link) - ↑ Krokowicz L, Kaczmarek BF, Krokowicz P, Stojcev Z, Mackiewicz J, Walkowiak J, Drews M, Banasiewicz T (2014). "Sodium butyrate and short chain fatty acids in prevention of travellers' diarrhoea: a randomized prospective study". Travel Med Infect Dis. 12 (2): 183–188. doi:10.1016/j.tmaid.2013.08.008. PMID 24063909.
Further reading
[edit]- Govindarajan, Nambirajan; Agis-Balboa, Roberto Carlos; Walter, Jonas; Sananbenesi, Farahnaz; Fischer, André (2011). "Sodium Butyrate Improves Memory Function in an Alzheimer's Disease Mouse Model When Administered at an Advanced Stage of Disease Progression". Journal of Alzheimer's Disease. 26 (1): 187–97. doi:10.3233/JAD-2011-110080. PMID 21593570.