Sodium channel opener

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A sodium channel opener is a type of drug which facilitates ion transmission through sodium channels.

Examples include toxins, such as aconitine, batrachotoxin, atracotoxin, robustoxin, versutoxin and ciguatoxins), and organochloride insecticides (DDT, pyrethrines, fenvalerate), which activate voltage-gated sodium channels (VGSCs), and solnatide (AP301), which activates the epithelial sodium channel (ENaC).[1]

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  1. ^ Shabbir W, Tzotzos S, Bedak M, Aufy M, Willam A, Kraihammer M, Holzner A, Czikora I, Scherbaum-Hazemi P, Fischer H, Pietschmann H, Fischer B, Lucas R, Lemmens-Gruber R (2015). "Glycosylation-dependent activation of epithelial sodium channel by solnatide". Biochem. Pharmacol. 98: 740–53. doi:10.1016/j.bcp.2015.08.003. PMID 26254591.