|AHFS/Drugs.com||International Drug Names|
|Chemical and physical data|
|Molar mass||481.409 g/mol|
|3D model (JSmol)|
|(what is this?)|
Sodium picosulfate (INN, also known as sodium picosulphate) is a contact stimulant laxative used as a treatment for constipation or to prepare the large bowel before colonoscopy or surgery. It is sold under the trade names Sodipic Picofast, Laxoberal, Laxoberon, Purg-Odan, Picolax, Guttalax, Namilax, Pico-Salax, PicoPrep, and Prepopik, among others.
Orally administered sodium picosulfate is generally used for thorough evacuation of the bowel, usually for patients who are preparing to undergo a colonoscopy. It takes 12–24 hours to work, since it works in the colon.
Abdominal cramps and diarrhea are normal effects of picosulfate and should be expected.
The use of sodium picosulfate has also been associated with certain electrolyte disturbances, such as hyponatremia and hypokalemia. Patients are often required to drink large amounts of clear fluids, to compensate for dehydration and to reestablish normal electrolyte balance.
Mechanism of action
Sodium picosulfate is a prodrug. It has no significant direct physiological effect on the intestine; however, it is metabolised by gut bacteria into the active compound 4,4'-dihydroxydiphenyl-(2-pyridiyl)methane (DPM, BPHM). This compound is a stimulant laxative and increases peristalsis in the gut.
Sodium picosulfate is typically prescribed in a combined formulation with magnesium citrate, an osmotic laxative. This combination is a highly effective laxative, often prescribed to patients for bowel cleansing prior to colonoscopies.
- Website of Merck Pakistan
- PICO SALAX Product Information Archived 2012-03-22 at the Wayback Machine.
- Tjandra, Joe J.; Chan, Miranda; Tagkalidis, Peter P. (2006). "Oral sodium phosphate (Fleet(R)) is a superior colonoscopy preparation to Picoprep(R) (sodium picosulfate-based preparation)". Diseases of the Colon & Rectum. 49 (5): 616–620. doi:10.1007/s10350-005-0323-2. PMID 16525746.
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- Regev, Arie; Fraser, Gerald; Delpre, George; Leiser, Alfredo; Neeman, Ami; Maoz, Eran; Anikin, Victor; Niv, Yaron. "Comparison of two bowel preparations for colonoscopy: sodium picosulphate with magnesium citrate versus sulphate-free polyethylene glycol lavage solution". The American Journal of Gastroenterology. 93 (9): 1478–1482. doi:10.1111/j.1572-0241.1998.00467.x.