Sodium tetradecyl sulfate

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Sodium tetradecyl sulfate
Sodium 7-ethyl-2-methyl-4-undecanyl sulfate.svg
Clinical data
Synonyms7-Ethyl-2-methyl-4-hendecanol sulfate sodium salt
AHFS/Drugs.comConsumer Drug Information
Routes of
administration
Intravenous injection
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
ECHA InfoCard100.004.892 Edit this at Wikidata
Chemical and physical data
FormulaC14H29NaO4S
Molar mass316.43243 g/mol
3D model (JSmol)
 ‹See TfM›☒N☑Y (what is this?)  (verify)

Sodium tetradecyl sulfate (STS) is a commonly used synonym for 7-ethyl-2-methyl-4-undecanyl sulfate sodium salt[1] which is anionic surfactant that is the active component of the sclerosant drug Sotradecol. It is commonly used in the treatment of varicose and spider veins of the leg, during the procedure of sclerotherapy. Being a detergent, its action is on the lipid molecules in the cells of the vein wall, causing inflammatory destruction of the internal lining of the vein and thrombus formation eventually leading to sclerosis of the vein. It is used in concentrations ranging from 0.1% to 3% for this purpose. In the UK, Ireland, Italy, Australia, New Zealand and South Africa, it is sold under the trade-name Fibro-Vein in concentrations of 0.2%, 0.5%, 1.0%, and 3%.[2]

Synthesis[edit]

It may be prepared by the aldol condensation of methyl isobutyl ketone and 2-ethylhexanal (which is itself formed by the aldol self-concensation of butyraldehyde), followed by sulfonation of the resulting alcohol.

References[edit]

  1. ^ "SOTRADECOL® (Sodium tetradecyl sulfate)" (PDF). Retrieved 29 August 2014.
  2. ^ Fibro-Vein history and details