Ionescu's interest in medicine began after she met one of her best friends Aurelia Dumitru, and her father Dr. Dumitru. The death of one of her school friends, who died in Paris due to an infection after brain surgery, impelled Ionescu to apply to medical school.
Supported by her mother, she applied to medical school in Bucharest in 1939. In her first internship year, she studied ophthalmology. Next year, she spent in Suceava at a poorly-equipped clinic during a typhus epidemic. During a school break, she volunteered to take care of Soviet prisoners at Stamate Hospital in Fălticeni. She entered the surgical service of the hospital, doing her first surgical operations, mostly amputations.
In October 1943, she became an intern at Hospital Nr. 9 in Bucharest. In 1944, during the bombing of Bucharest, she was forced to perform an emergency brain surgery on an injured boy due to lack of sufficient medical staff. In 1945, she became certified in medicine and surgery.
She was a neurosurgeon for 47 years at Hospital Nr. 9, forming a team with Ionel Ionescu, and Constantin Arseni, under the guidance of Dumitru Bagdasar. They formed the first neurological team of Romania, later called “The golden team”, which helped develop neurosurgery in Romania.
In 1970, the favorite wife of the Sheikh of Abu Dhabi had become ill. As a man could not enter the harem, they needed to find a female doctor. Ionescu stayed one week at the woman’s side and cured her. As a reward the sheik gave her 2,000 dollars and an expensive piece of jewelry. She died on 21 March 2008 in Bucharest.
- Micutariu, Daniela (24 March 2008). "Fălticeneanca Sofia Ionescu-Ogrezeanu a murit, la 88 de ani". Monitorul. Retrieved 2 August 2011.
- Mihailide, Mihail (5 December 2011) O legendă a neurochirurgiei româneşti. viata-medicala.ro.
- Sofia Ionescu-Ogrezeanu, prima femeie neurochirurg din lume. tvr.ro (25 April 2014).
- "Interview with Sofia Ionescu-Ogrezeanu". TVR.
- Daniela Micutariu. "Falticeneanca Sofia Ionescu-Ogrezeanu a murit la 88 de ani". Monitorul. Retrieved 26 April 2011.
- "The Imprint of a Scalpel". Union Radiophonique et Télévisuelle Internationale. Retrieved 26 April 2011.
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