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Somatopause is the progressive decline in the levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), hormones of the hypothalamic–pituitary–somatotropic axis (HPS axis), with age.[1] Secretion of GH may only be 60% of that of a young adult by age 70 years.[2] Somatopause results in changes in the body, such as body composition changes like a decrease in lean body mass.[1] Estrogens and progesterone may oppose somatopause by increasing GH and IGF-1 levels.[1]


  1. ^ a b c J. Larry Jameson; Leslie J. De Groot (25 February 2015). Endocrinology: Adult and Pediatric E-Book. Elsevier Health Sciences. pp. 2315–. ISBN 978-0-323-32195-2.
  2. ^ Roy G. Smith; Michael O. Thorner (28 January 2000). Human Growth Hormone: Research and Clinical Practice. Springer Science & Business Media. pp. 325–. ISBN 978-1-59259-015-5.