Somatostatin receptor 2

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SSTR2
Identifiers
Aliases SSTR2, Somatostatin receptor 2
External IDs MGI: 98328 HomoloGene: 37427 GeneCards: SSTR2
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SSTR2
Genomic location for SSTR2
Band 17q25.1 Start 73,165,012 bp[1]
End 73,176,633 bp[1]
RNA expression pattern
PBB GE SSTR2 214597 at fs.png

PBB GE SSTR2 217455 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001050

NM_001042606
NM_009217

RefSeq (protein)

NP_001041

NP_001036071
NP_033243

Location (UCSC) Chr 17: 73.17 – 73.18 Mb Chr 17: 113.62 – 113.63 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene.[5]

Function[edit]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.[6]

Interactions[edit]

Somatostatin receptor 2 has been shown to interact with SHANK2.[7]

Therapeutic targeting[edit]

Most pituitary adenomas express SSTR2, but other somatostatin receptors are also found.<[8] Somatostatin analogs (i.e. Octreotide, Lanreotide ) are used to stimulate this receptors, and thus to inhibit further tumor proliferation.[9]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180616 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047904 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Yamada Y, Stoffel M, Espinosa R, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (Feb 1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. PMID 8449518. doi:10.1006/geno.1993.1088. 
  6. ^ "Entrez Gene: SSTR2 somatostatin receptor 2". 
  7. ^ Zitzer H, Hönck HH, Bächner D, Richter D, Kreienkamp HJ (Nov 1999). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". The Journal of Biological Chemistry. 274 (46): 32997–3001. PMID 10551867. doi:10.1074/jbc.274.46.32997. 
  8. ^ Miller GM, Alexander JM, Bikkal HA, Katznelson L, Zervas NT, Klibanski A (Apr 1995). "Somatostatin receptor subtype gene expression in pituitary adenomas". The Journal of Clinical Endocrinology and Metabolism. 80 (4): 1386–92. PMID 7714115. doi:10.1210/jcem.80.4.7714115. 
  9. ^ Zatelli MC, Ambrosio MR, Bondanelli M, Uberti EC (Apr 2007). "Control of pituitary adenoma cell proliferation by somatostatin analogs, dopamine agonists and novel chimeric compounds". European Journal of Endocrinology / European Federation of Endocrine Societies. 156 Suppl 1: S29–35. PMID 17413185. doi:10.1530/eje.1.02352. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.