Sonodynamic therapy, also described as activated therapy, ultrasound activated PDT, sonophotodynamic therapy and other terms, with no clear distinction in usage, is an alternative cancer therapy which claims to use ultrasound and light to enhance the cytotoxic effects of drugs described as "sonosensitizers". It has been tested in vitro and in animals, but the results are not considered compelling and it is rejected by mainstream science.
Independent evidence of effect is lacking, such studies as have been published are in low impact factor journals, including journals specialising in "alternative" therapies.
It is cited as one of the motivations for an unprecedented initiative by health authorities in the UK, warning patients about unproven cancer treatments.
- Cancer patients warned against clinics offering unproven treatments, The Guardian, 30 November 2012
- Rosenthal I, Sostaric JZ, Riesz P (September 2004). "Sonodynamic therapy--a review of the synergistic effects of drugs and ultrasound". Ultrasonics Sonochemistry. 11 (6): 349–63. PMID 15302020. doi:10.1016/j.ultsonch.2004.03.004.
- Xiaohuai Wang; Lewis TJ; Mitchell D (June 2008). "The tumoricidal effect of sonodynamic therapy (SDT) on S-180 sarcoma in mice". Integrative Cancer Therapies. 7 (2): 96–102. PMID 18550890. doi:10.1177/1534735408319065.