Lowe's first roles were the short films Kindle, in which she played the lead role Hayley; Mirage, which was screened at the Montreal World Film Festival, and He. She. It., as well as a number of television advertisements before she graduated from The McDonald College in 2008.
In 2013, Lowe and her fellow McDonald College alumnus Rhys Wakefield co-wrote, co-directed, and starred in the short film A Man Walks Into a Bar... The film was a finalist at Sydney's Tropfest short film festival. Lowe and Wakefield previously worked together in the 2013 film After the Dark.
Lowe is also a singer-songwriter, performing under the alias SOLO. In December 2013, she released a five-song EP named after her alias, released by the online music retailer Bandcamp. The music video for the song "Dreaming", one of the songs from the SOLO EP, was directed by actress and After the Dark co-star Bonnie Wright.