D-arabinofuranosyl-5-[( E)-2-bromovinyl]pyrimidine-2,4(1 H,3 H)-dione
Metabolism Viral thymidine kinase
CAS Registry Number
BV-araU, Bromovinyl araU, 5-Bromovinyl-araU, 5-[( E)-2-bromoethenyl]-1-[(2 R,3 S,4 S,5 R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
C 11 H 13 Br N 2 O 6
Molecular mass 349.14 g/mol
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Sorivudine ( INN) chemical name (E)-5-(2-Bromovinyl)- 1β-D-arabinofuranosyluracil, is a thymine analogue antiviral drug, marketed under trade names such as Usevir ( Nippon Shoji, Eisai) and Brovavir ( BMS).
Pharmacology [ edit ]
Feature [ edit ]
First-line treatment of herpes drug acyclovir was (Zovirax, Activir) from VZV strong activity of the virus.
Superior gastrointestinal absorption, absorption from the gastrointestinal tract after the most degrading without being excreted as urine.
Mechanism of action [ edit ]
Sorivudine is phosphorylated by thymidine kinase activity in the body and is absorbed into the virus's DNA instead of the correct nucleoside. It is a competitive inhibitor of DNA polymerase, so the viral DNA cannot be replicated and the virus cannot grow.
Microbiology [ edit ]
Sorivudine is active against most species in the