Between its source and Newmains it follows a wide glacial valley and passes the village of Bonkle and Murdostoun Castle, but after Newmains ...until its end at Strathclyde Loch in Motherwell, it cuts through a very deep and meandering valley. This valley was filled in at Ravenscraig during the construction of Ravenscraig steelworks to provide a large flat area. The river is therefore placed in a "cut and cover" tunnel as it passes for approximately 1/2 mile underneath the site, before reappearing at Jerviston. Driving across the now derelict Ravenscraig site gives no clues as to the underground river flowing below.
The river ends at Strathclyde Loch, where it used to join directly with the River Clyde. The River Clyde was diverted about 1 mile west of this point in the 1960s to create the large man made loch, which is now fed purely by water from the South Calder Water.