The team has been to 11 NCAA Tournaments and served as an NCAA Regional host in 2003. The Southern Miss baseball team has produced 19 All-Americans. and currently has 4 players on Major League rosters. Southern Miss has won three Conference USA Regular Season Championships (2003, 2011, 2013) and two Tournament Championships (2003, 2010) and is the only team in CUSA to participate in every conference baseball tournament since the conference's inception. The Golden Eagles rich history began in 1912 with a game against the Detroit Tigers, a contest which Southern Miss lost by a score of 24–2. The Golden Eagles play at Pete Taylor Park/Hill Denson Field on the campus of the University of Southern Mississippi and consistently rank in the top 20 nationally in NCAA attendance figures.
Southern Miss qualified for its first College World Series in 2009 after winning the Atlanta Regional and the Gainesville Super Regional. They would post an 0–2 record in Omaha, losing 7–6 against top-seeded Texas and 11–4 versus fourth-seeded North Carolina.