Sp8 transcription factor

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SP8
Identifiers
Aliases SP8, BTD, Sp8 transcription factor
External IDs MGI: 2443471 HomoloGene: 18548 GeneCards: SP8
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_182700
NM_198956

NM_177082

RefSeq (protein)

NP_874359
NP_945194

NP_796056

Location (UCSC) Chr 7: 20.78 – 20.79 Mb Chr 12: 118.85 – 118.85 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor Sp8 also known as specificity protein 8 (SP-8) or Btd transcription factor (buttonhead)[3] is a protein that in humans is encoded by the SP8 gene.[4][5] Sp8 is a transcription factor in the Sp/KLF family.

Function[edit]

Sp8 mediates limb outgrowth during early development.[3] Sp8 deletion in mice resulted in severe exencephaly.[6] Sp8 is a zinc-finger transcription factor. The structural difference between Sp8 and Sp9 is only one amino acid. These transcription factors are Apical Ectodermal Ridge (AER) specific in limb development. The Apical Ectodermal Ridge signaling is important for specification of distal limb structures. Sp8 and Sp9 mediate Fgf10 signaling, which in turn regulates Fgf8 expression (Fgf10--->Fgf8). Fgf8 is essential for normal limb development, and without the presence of Fgf8 in early development, there would be a decreased length of the limb bud and possible failure of the limb tissue develop. Both Sp8 and Sp9 have been found in vertebrates. Although, so far only Sp8 has been proven to be present in invertebrates too. Under lab conditions, Sp8 replaced btd in Drosophila, showing that Sp8 and btd both have similar functions in limb development in both vertebrates and invertebrates. Gene knockdown in zebrafish displayed that Fgf8 expression is necessary for appendage development.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Treichel D, Schöck F, Jäckle H, Gruss P, Mansouri A (November 2003). "mBtd is required to maintain signaling during murine limb development". Genes & Development. 17 (21): 2630–5. PMC 280612Freely accessible. PMID 14597661. doi:10.1101/gad.274103. 
  4. ^ Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ (October 2003). "Sp8 is crucial for limb outgrowth and neuropore closure". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12195–200. PMC 218735Freely accessible. PMID 14526104. doi:10.1073/pnas.2134310100. 
  5. ^ "Entrez Gene: Sp8 transcription factor". 
  6. ^ Waclaw RR, Allen ZJ, Bell SM, Erdélyi F, Szabó G, Potter SS, Campbell K (February 2006). "The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons". Neuron. 49 (4): 503–16. PMID 16476661. doi:10.1016/j.neuron.2006.01.018. 
  7. ^ Kawakami Y, Esteban CR, Matsui T, Rodríguez-León J, Kato S, Izpisúa Belmonte JC (October 2004). "Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos". Development. 131 (19): 4763–74. PMID 15358670. doi:10.1242/dev.01331. 

Further reading[edit]