Sp8 transcription factor

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Sp8 transcription factor
Symbols SP8 ; BTD
External IDs OMIM608306 MGI2443471 HomoloGene18548 GeneCards: SP8 Gene
Species Human Mouse
Entrez 221833 320145
Ensembl ENSG00000164651 ENSMUSG00000048562
UniProt Q8IXZ3 Q8BMJ8
RefSeq (mRNA) NM_182700 NM_177082
RefSeq (protein) NP_874359 NP_796056
Location (UCSC) Chr 7:
20.78 – 20.79 Mb
Chr 12:
118.85 – 118.85 Mb
PubMed search [1] [2]

Transcription factor Sp8 also known as specificity protein 8 (SP-8) or Btd transcription factor (buttonhead)[1] is a protein that in humans is encoded by the SP8 gene.[2][3] Sp8 is a transcription factor in the Sp/KLF family.


Sp8 mediates limb outgrowth during early development.[1] Sp8 deletion in mice resulted in severe exencephaly.[4]


  1. ^ a b Treichel D, Schöck F, Jäckle H, Gruss P, Mansouri A (November 2003). "mBtd is required to maintain signaling during murine limb development". Genes Dev. 17 (21): 2630–5. doi:10.1101/gad.274103. PMC 280612. PMID 14597661. 
  2. ^ Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ (October 2003). "Sp8 is crucial for limb outgrowth and neuropore closure". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12195–200. doi:10.1073/pnas.2134310100. PMC 218735. PMID 14526104. 
  3. ^ "Entrez Gene: Sp8 transcription factor". 
  4. ^ Waclaw RR, Allen ZJ, Bell SM, Erdélyi F, Szabó G, Potter SS, Campbell K (February 2006). "The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons". Neuron 49 (4): 503–16. doi:10.1016/j.neuron.2006.01.018. PMID 16476661. 

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