Sp8 transcription factor

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SP8
Identifiers
Aliases SP8, BTD, Sp8 transcription factor
External IDs MGI: 2443471 HomoloGene: 18548 GeneCards: SP8
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_182700
NM_198956

NM_177082

RefSeq (protein)

NP_874359
NP_945194

NP_796056.2
NP_796056

Location (UCSC) Chr 7: 20.78 – 20.79 Mb Chr 12: 118.85 – 118.85 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor Sp8 also known as specificity protein 8 (SP-8) or Btd transcription factor (buttonhead)[3] is a protein that in humans is encoded by the SP8 gene.[4][5] Sp8 is a transcription factor in the Sp/KLF family.

Function[edit]

Sp8 mediates limb outgrowth during early development.[3] Sp8 deletion in mice resulted in severe exencephaly.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Treichel D, Schöck F, Jäckle H, Gruss P, Mansouri A (November 2003). "mBtd is required to maintain signaling during murine limb development". Genes Dev. 17 (21): 2630–5. doi:10.1101/gad.274103. PMC 280612Freely accessible. PMID 14597661. 
  4. ^ Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ (October 2003). "Sp8 is crucial for limb outgrowth and neuropore closure". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12195–200. doi:10.1073/pnas.2134310100. PMC 218735Freely accessible. PMID 14526104. 
  5. ^ "Entrez Gene: Sp8 transcription factor". 
  6. ^ Waclaw RR, Allen ZJ, Bell SM, Erdélyi F, Szabó G, Potter SS, Campbell K (February 2006). "The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons". Neuron. 49 (4): 503–16. doi:10.1016/j.neuron.2006.01.018. PMID 16476661. 

Further reading[edit]