Perisinusoidal space

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Perisinusoidal space
Sinusoid of a rat liver with fenestrated endothelial cells. Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm. Scanning electron micrograph by Robin Fraser, University of Otago.
Hepatic structure2.svg
Basic liver structure
Latin spatium perisinusoideum
Code TH H3.
Anatomical terminology

The perisinusoidal space (or space of Disse) is a location in the liver between a hepatocyte and a sinusoid. It contains the blood plasma. Microvilli of hepatocytes extend into this space, allowing proteins and other plasma components from the sinusoids to be absorbed by the hepatocytes. Fenestration and discontinuity of the endothelium, as well as its basement membrane,[1] facilitates this transport.[2] This space may be obliterated in liver disease, leading to decreased uptake by hepatocytes of nutrients and wastes (like bilirubin, for example).

The Space of Disse also contains Ito cells, also called hepatic stellate cells, which store fat or fat soluble vitamins (like vitamin A). A variety of insults that cause inflammation can result in Ito cells transforming to myofibroblasts, resulting in collagen production, fibrosis, and cirrhosis.

The Space of Disse was named after German anatomist Joseph Disse (1852–1912).[3]


  1. ^ Mescher, Anthony L. "The Circulatory System." Junquiera's Basic Histology. 12th Ed. New York: McGraw-Hill, 2010. Print. 197.
  2. ^ Robbins, Stanley L.; Cotran, Ramzi S.; Kumar, Vinay; Collins, Tucker (1999). Robbins pathologic basis of disease. Philadelphia: Saunders. ISBN 0-7216-7335-X. 
  3. ^ Haubrich WS (2004). "Disse of the space of Disse". Gastroenterology 127 (6): 1684. doi:10.1053/j.gastro.2004.10.021. PMID 15578505. 

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