Spectrin repeat

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Spectrin repeat
PDB 1aj3 EBI.jpg
Structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil.[1]
Identifiers
Symbol Spectrin
Pfam PF00435
InterPro IPR002017
PROSITE PDOC50083
SCOP 1aj3
SUPERFAMILY 1aj3
OPM superfamily 79
OPM protein 2spc
CDD cd00176

Spectrin repeats[2] are found in several proteins involved in cytoskeletal structure. These include spectrin, alpha-actinin, dystrophin and more recently the plakin family. The spectrin repeat forms a three-helix bundle. These conform to the rules of the heptad repeat. Spectrin repeats give rise to linear proteins. This however may be due to sample bias in which linear and rigid structures are more amenable to crystallization. There are hints however, that some proteins harbouring spectrin repeats may also be flexible. This is most likely due to specifically evolved functional purposes.

Human proteins containing this domain[edit]

ACTN1; ACTN2; ACTN3; ACTN4; AKAP6; SYNE3; CATX-15; DMD; DRP2; DST; KALRN; MACF1; MCF2L; SPTA1; SPTAN1; SPTB; SPTBN1; SPTBN2; SPTBN4; SPTBN5; SYNE1; SYNE2; TRIO; UTRN;

References[edit]

  1. ^ Pascual J, Pfuhl M, Walther D, Saraste M, Nilges M (October 1997). "Solution structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil". J. Mol. Biol. 273 (3): 740–51. doi:10.1006/jmbi.1997.1344. PMID 9356261. 
  2. ^ Harrison SC, Yan Y, Winograd E, Viel A, Cronin T, Branton D (1993). "Crystal structure of the repetitive segments of spectrin". Science. 262 (5142): 2027–2030. doi:10.1126/science.8266097. PMID 8266097. 

Further reading[edit]

  • Djinovic-Carugo K, Gautel M, Ylänne J, Young P (February 2002). "The spectrin repeat: a structural platform for cytoskeletal protein assemblies". FEBS Lett. 513 (1): 119–23. doi:10.1016/S0014-5793(01)03304-X. PMID 11911890. 
  • Pascual J, Castresana J, Saraste M (September 1997). "Evolution of the spectrin repeat". BioEssays. 19 (9): 811–7. doi:10.1002/bies.950190911. PMID 9297972. 
  • Al-Jassar, C; Knowles, T; Jeeves, M; Kami, K; Behr, E; Bikker, H; Overduin, M; Chidgey, M (Jul 2, 2011). "The Nonlinear Structure of the Desmoplakin Plakin Domain and the Effects of Cardiomyopathy-Linked Mutations.". Journal of Molecular Biology. 411 (5): 1049–61. doi:10.1016/j.jmb.2011.06.047. PMID 21756917.