|Micrograph of a spermatocytic seminoma. H&E stain.|
|Classification and external resources|
Relation to seminoma
Spermatocytic seminoma is not considered a subtype of seminoma and, unlike seminoma and most other germ cell tumours, it does not arise from intratubular germ cell neoplasia. It has not been described as arising in locations outside the testis, and does not occur in association with other germ cell tumours.
The new WHO classification, due to be published in 2016, will rename the condition spermatocytic tumour to avoid confusion with classical seminoma as the biology and treatment are different.
Spermatocytic seminoma is a rare tumour, making up only one to two percent of all testicular germ cell tumours. Men presenting with this tumour are generally 50 to 60 years old, and its occurrence is rare in men under 30 years old. Most present with slow, painless testicular enlargement, which may involve both testes.
- small cells with a large nuclear-to-cytoplasmic ratio (6-8 µm),
- medium-sized cells with prominent nucleoli (15-18 µm) and,
- large cells (50-100 µm).
The cells are generally packed into nodules, and have a loose, sheet-like arrangement that is commonly interrupted by interstitial oedema. Unlike classical seminoma, fibrous septation and lymphocytic infiltrates are not seen. Cells undergoing mitosis are common, as are cells undergoing apoptosis.
Intratubular growth of spermatocytic seminoma can be seen, however there is no intratubular germ cell neoplasia of unspecified type (IGCNU). The intratubular growth probably accounts for the appearance of separate tumour nodules within the testis.
Immunostaining for most of the usual testicular germ cell tumour markers is negative (i.e. placental alkaline phosphatase (PLAP), vimentin, actin, desmin, alpha fetoprotein (AFP), OCT4, human chorionic gonadotropin (hCG), and carcinoembryonic antigen (CEA)).
Rarely, spermatocytic seminomas may show sarcomatoid differentiation, most commonly as undifferentiated spindled cells intermingled within the typical-appearing spermatocytic seminoma cells. Rhabdomyosarcomatous differention has also been described.
Unlike classical seminoma, spermatocytic seminomas rarely metastasise, so radical orchidectomy alone is sufficient treatment, and retroperitoneal lymph node dissection and adjuvant chemotherapy or radiotherapy are generally not required.
- Müller J, Skakkebaek NE, Parkinson MC (February 1987). "The spermatocytic seminoma: views on pathogenesis". Int. J. Androl. 10 (1): 147–56. doi:10.1111/j.1365-2605.1987.tb00176.x. PMID 3583416.
- Mills, S (ed.) 2009.Sternberg's Diagnostic Pathology. 5th Edition. ISBN 978-0-7817-7942-5
- Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. ISBN 0-7216-0187-1.
- Spermatocytic seminoma micrograph - webpathology.com.